Author/Authors :
Yan, Sujun Hong Kong Baptist University - Department of Chemistry and Central Laboratory of the Institute of Molecular Technology for Drug Discoveryand Synthesis, China , Lam, K.T. Hong Kong Baptist University - Department of Chemistry and Central Laboratory of the Institute of Molecular Technology for Drug Discoveryand Synthesis, China , Mo, K.T. Hong Kong Baptist University - Department of Chemistry and Central Laboratory of the Institute of Molecular Technology for Drug Discoveryand Synthesis, China , Wong, W.Y. Hong Kong Baptist University - Department of Chemistry and Central Laboratory of the Institute of Molecular Technology for Drug Discoveryand Synthesis, China , Chan, W.H. Hong Kong Baptist University - Department of Chemistry and Central Laboratory of the Institute of Molecular Technology for Drug Discoveryand Synthesis, China , Lee, Albert W.M. Hong Kong Baptist University - Department of Chemistry and Central Laboratory of the Institute of Molecular Technology for Drug Discoveryand Synthesis, China
Abstract :
Chiral secondary amines of the 3,4-dimethoxyphenylethyl and the tryptamine system were reactedwith chiral acetylenic sulfoxides and achiral acetylenic sulfone. In the case of 3,4-dimethoxyphenylethylamine, much improved diastereoselectivity (96 : 4) was observed as compared to the reaction of achiralsecondary amine with chiral acetylenic sulfoxides.
Keywords :
Chiral sulfoxide , asymmetric synthesis , alkaloid synthesis , diastereoselectivity
