Author/Authors :
Bonora, G.M. Università di Trieste - Dipartimento di Scienze Chimiche, Italy , Drioli, S. Università di Trieste - Dipartimento di Scienze Chimiche, Italy , Forzato, C. Università di Trieste - Dipartimento di Scienze Chimiche, Italy , Nitti, P. Università di Trieste - Dipartimento di Scienze Chimiche, Italy , Pitacco, G. Università di Trieste - Dipartimento di Scienze Chimiche, Italy
Abstract :
Bioreduction of PEG-acetoacetate 1 is achieved using dry baker s yeast in toluene with a smallamount of added water. After detachment from the polymer under basic conditions, the corresponding (S)-(+)-3-hydroxybutanoic acid 3 was esterified with Me3SiCl and ethanol and ethyl (S)-(+)-3-hydroxybutanoate 4 was isolated with 97% e.e. and 70% overall yield.
Keywords :
Baker’s yeast , bioreduction , organic solvent , PEG
