Title of article :
Mild and Facile Deprotection for the Synthesis of Oligodeoxynucleotide Incorporating a 6-0-Ethyl-deoxyguanosine
Author/Authors :
Seio, Kohji Tokyo Institute of Technology - Frontier Collaborative Research Center, Japan , Seio, Kohji JST (Japan Science and Technology Agency) - CREST, Japan , Negishi, Tomoe Okayama University - Faculty of Pharmaceutical Sciences, Japan , Negishi, Kazuo Okayama University - Advanced Science Research Center, Japan , Sekine, Mitsuo Tokyo Institute of Technology - Department of Life Science , Sekine, Mitsuo JST (Japan Science and Technology Agency) - CREST, Japan
Abstract :
The phenoxyacetyl (Pac) group proved to be useful for the synthesis of oligodeoxyribonucleotidesincorporating a 6-0-ethylguanine. Since the Pac group could be removed by mild treatment with ammonia, formation of a 2, 4-diaminopurine derivative was avoided. Moreover, the use of the Pac group resulted in significant suppression of the depurination of 6-0-ethyldeoxyguanosine.
Keywords :
6 , 0 , ethylguanine , degenerated base , mutation , phenoxyacetyl group , depurination , oligodeoxynucleotide synthesis
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
