Title of article :
Structure/Activity Relationship of Carba- and C-Fucopyranosides asInhibitors of an α 1,6-Fucosyltransferase by Molecular Modeling and Kinetic Studies
Author/Authors :
Calderón, Félix CSIC - Instituto de Química Orgánica General, Spain , Carpintero, Mercedes CSIC - Instituto de Química Orgánica General, Spain , García-Junceda, Eduardo CSIC - Instituto de Química Orgánica General, Spain , Fernández-Mayoralas, Alfonso CSIC - Instituto de Química Orgánica General, Spain , Bastida, Agatha CSIC - Instituto de Química Orgánica General, Spain
Abstract :
Several carba- and C-fucopyranosides have been tested as inhibitors of recombinant α 1,6-Fucosyltransferase from Rhizobium sp. 1-(R)-amino-phenylmethyl C-fucopyranoside (7) with 4C1(L)conformation showed the highest inhibition (IC50 = 690 μM). Molecular modeling alloweded us to establish an structure/activity relationship for the carba- and C-fucopyranosides inhibition activity
Keywords :
Glycosyltransferases , inhibitors , C , Glycosides , carbocycles , molecular mechanics calculations
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
