Title of article
Highly Stereoselective Alkynylation with Steroidal Alkyne: Efficient Pathway to 24(S) or 24(R)-Hydroxylcholesterol
Author/Authors
Jiang, Biao Chinese Academy of Sciences - Shanghai Institute of Organic Chemistry, P. R. China , Chen, Zi-li Chinese Academy of Sciences - Shanghai Institute of Organic Chemistry, P. R. China , Huang, Hao Chinese Academy of Sciences - Shanghai Institute of Organic Chemistry, P. R. China
From page
319
To page
322
Abstract
24(S)- or 24(R)-Hydroxyl cholesterol was prepared in high stereoselectivity (up to 99% de),utilizing asymmetric alkynylation of isobutyraldehyde with steroidal alkyne catalyzed by Zn(OTf)2respectively in the presence of (1S, 2S)-3-(t-butyldimethylsilyloxyl)-2-N, N-dimethylamino-1-(p-nitrophenyl)-propane-1-ol or its (1R, 2R)-enantiomer.
Keywords
Asymmetric alkynylation , hydroxylcholesterol , hyodeoxycholic acid.
Journal title
letters in organic chemistry
Journal title
letters in organic chemistry
Record number
2717861
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