Title of article :
A Facile Synthesis of N,N’-bis[Formamidine]ureas and Symmetrical N,N’-Disubstituted Formamidines
Author/Authors :
Díaz, D.D., ` The Scripps Research Institute - The Skaggs Institute for Chemical Biology - Department of Chemistry, USA , Finn, M.G. The Scripps Research Institute - Institute for Chemical Biology - Department of Chemistry and The Skaggs, USA
Abstract :
The reactivity of N,N’-bis[(E)-dimethylamino)methylene]urea (1) with amines is described. Selective exchange of one of the N,N-dimethylamino fragments is possible with most of the benzylic amines tested,allowing the formation of 1-(alkylamino-methylene)-3-dimethylaminomethylene ureas as analytically pure precipitates in modest yields. Under acidic conditions, the urea fragment acts as leaving group leading theformation of symmetrical N,N’-disubstituted formamidines.
Keywords :
Urea , formamidine , synthesis , amines , transamination reactions , acid , hydrolysis
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
