Title of article
Short Synthesis of the Selective Rho-Kinase Inhibitor Y-27632 and of ItsEnantiomer
Author/Authors
Belotti, Damien Laboratoire de Chimie Organique associé au CNRS, France , Peglion, Jean Louis Institut de Recherches Servier, France , Cossy, Janine Laboratoire de Chimie Organique associé au CNRS, France
From page
634
To page
636
Abstract
Y-27632 and its enantiomer were synthesized in 8 steps from trans-1,4-cyclohexanedicarboxylicacid by using a diastereoselective reductive amination of a ketone.
Keywords
Kinase inhibitor , Y , 27632 , Rho , associated kinase , reductive amination
Journal title
letters in organic chemistry
Journal title
letters in organic chemistry
Record number
2717920
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