Title of article :
Short Synthesis of the Selective Rho-Kinase Inhibitor Y-27632 and of ItsEnantiomer
Author/Authors :
Belotti, Damien Laboratoire de Chimie Organique associé au CNRS, France , Peglion, Jean Louis Institut de Recherches Servier, France , Cossy, Janine Laboratoire de Chimie Organique associé au CNRS, France
Abstract :
Y-27632 and its enantiomer were synthesized in 8 steps from trans-1,4-cyclohexanedicarboxylicacid by using a diastereoselective reductive amination of a ketone.
Keywords :
Kinase inhibitor , Y , 27632 , Rho , associated kinase , reductive amination
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
