Title of article :
(Salen)Ti(IV)-Catalyzed Asymmetric Ring-Opening of Monosubstituted Epoxides with Dithiophosphorus Acid
Author/Authors :
Zhou, Zhenghong Nankai University - Institute of Elemento-Organic Chemistry - State Key Laboratory of Elemento-Organic Chemistry, China , Wang, Quanyong Nankai University - Institute of Elemento-Organic Chemistry - State Key Laboratory of Elemento-Organic Chemistry, China , Liu, Bing Nankai University - Institute of Elemento-Organic Chemistry - State Key Laboratory of Elemento-Organic Chemistry, China , Zhao, Guofeng Nankai University - Institute of Elemento-Organic Chemistry - State Key Laboratory of Elemento-Organic Chemistry, China , Zhou, Qilin Nankai University - Institute of Elemento-Organic Chemistry - State Key Laboratory of Elemento-Organic Chemistry, China , Tang, Chuchi Nankai University - Institute of Elemento-Organic Chemistry - State Key Laboratory of Elemento-Organic Chemistry, China
Abstract :
The asymmetric ring-opening of monosubstituted epoxides with dithiophosphorus acids catalyzedby a (salen)Ti(IV) complex formed in situ from the reaction of Ti(OPr-i)4 and the chiral salen ligand derivedfrom (1R,2R)-(+)-diaminocyclohexane and (R)-2,2’-diamino-1,1’- binaphthalene was realized. The resulting products were obtained with moderate enantioselectivity (up to 57% ee). High regioselectivity was observedfor the alkyl substituted epoxides, whereas poor regioselectivity was obtained for the aryl substituted epoxides.
Keywords :
(Salen)Ti(IV) complex , asymmetric ring , opening , monosubstituted epoxides , regioselectivity , enantioselectivity
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
