Title of article :
Chromium Trioxide Supported on NaHSO4.H2O: Efficient Oxidative Deprotection of Trimethylsilyl Ethers in Solution and Under Solvent FreeConditions
Author/Authors :
Yu, Haifeng , Dong, Dewen Northeast Normal University - Dpartment of Chemistry, China , Ouyang, Yan Northeast Normal University - Dpartment of Chemistry, China , Liu, Qun Northeast Normal University - Dpartment of Chemistry, China , Wang, Yan Northeast Normal University - Dpartment of Chemistry, China
Abstract :
4,4-Bis(ethylthio)but-3-en-2-one 1a and 4,4-bis(benzylthio)but-3-en-2- one 1b have been investigated as non-thiolic and odorless thiol equivalents in thio-Michael addition. Promoted by acetylchloride in methanol, the cleavage of compounds 1a and 1b commenced and the in-situ generated thiolsunderwent facile acid-catalyzed conjugate addition to α,β-unsaturated ketones 2 affording the correspondingb-keto sulfides 3 in good yields.
Keywords :
Chromium trioxide , oxidative deprotection , NaHSO4.H2O , solvent free conditions , trimethylsilyl ethers
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
