Title of article :
Complete 1,3-Asymmetric Induction into 3-Methyl-4-(3-Acetylpyrrol-1-yl)Butanal to 1-Acetyl-6-Methyl-8-Hydroxy-5,6,7,8-Tetrahydroindolizine Cyclization
Author/Authors :
Settambolo, Roberta Università di Pisa - Dipartimento di Chimica e Chimica Industriale, Italy , Rocchiccioli, Silvia Università di Pisa - Dipartimento di Chimica e Chimica Industriale, Italy , Lazzaroni, Raffaello Università di Pisa - Dipartimento di Chimica e Chimica Industriale, Italy , Alagona, Giuliano IPCF-CNR, Italy
Abstract :
The formation of 1-acetyl-6-methyl-8-hydroxy-5,6,7,8-tetrahydroindolizine (3) from 3-methyl-4-(3-acetylpyrrol-1-yl)butanal (2), coming from the rhodium catalyzed hydroformylation of 2-methyl-3-(3-acetylpyrrol-1-yl)prop-1-ene (1), is reported. Evidences for both the complete diastereoselective cyclization of2 and the configuration determination in 3 via 1H, 13 C and IR spectra are reported.
Keywords :
1 , 3 , asymmetric induction , hydroformylation , hydroxytetrahydroindolizines , rhodium , catalyst , pyrrolylbutanal
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
