Title of article :
Synthesis of C7-Substituted Estra-1,3,5(10),6-Tetraen-3,17 β-Diols
Author/Authors :
Morais, Goreti Ribeiro University of Lisbon - Faculty of Pharmacy, Portugal , Morais, Goreti Ribeiro Kyushu University - Institute of Materials Chemistry and Engineering, Japan , Oliveirac, Maria Cristina das Neves Instituto Tecnológico e Nuclear, Portugal , Thiemann, Thies Kyushu University - Institute of Materials Chemistry and Engineering, Japan
Abstract :
A series of C7-substituted estra-1,3,5(10),6-tetraene-3,17b-diols were prepared as precursors toradiodiagnostic agents of breast cancer. The introduction of the olefin moiety at C6/C7 in the molecules was achieved through thermal elimination of the 6-hydroxy group in the corresponding estra-1,3,5(10)-triene-3,17b-diols.
Keywords :
Estranes , steroids , conjugate addition , thermal dehydration
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
