Title of article
Efficient Diastereoselective Titanium(IV) Reductive Amination of Ketones
Author/Authors
Salmi, Chanaz Université Paul Cézanne - Faculté des Sciences et Techniques de St Jérôme - Laboratoire Synthèse et Etude de Substances Naturelles à Activités Biologiques (SESNAB), France , Letourneux, Yves Université Paul Cézanne - Faculté des Sciences et Techniques de St Jérôme - Laboratoire Synthèse et Etude de Substances Naturelles à Activités Biologiques (SESNAB), France , Brunel, Jean Michel Université Paul Cézanne - Faculté des Sciences et Techniques de St Jérôme - Laboratoire Synthèse et Etude de Substances Naturelles à Activités Biologiques (SESNAB), France
From page
384
To page
389
Abstract
An efficient method for the diastereoselective synthesis of various secondary amines through atitanium(IV) isopropoxide–mediated reductive amination reaction of ketones is reported. Thus, a series of different ketones and (R)-Phenylethylamine were involved leading to the expected products in moderate to excellent yields and importantly in diastereoselectivities up to 100% in one case.
Keywords
Titanium , Reductive amination , Ketones , Secondary amines , Imines , Diastereoselectivity
Journal title
letters in organic chemistry
Journal title
letters in organic chemistry
Record number
2718013
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