مرکز منطقه ای اطلاع رساني علوم و فناوري - A Concise Total Synthesis of 7-Substituted Eudistomin Analogs

Title of article :

A Concise Total Synthesis of 7-Substituted Eudistomin Analogs

Author/Authors :

Peng, Zuozhong Wu Xi Pharma Tech Co., Ltd., China , Song, Ji 1WuXi Pharma Tech Co., Ltd., China , Liao, Wensheng Wu Xi PharmaTech Co., Ltd., China , Ma, Rujian Wu Xi PharmaTech Co., Ltd., No., China , Chen, Shu-Hui Wu Xi PharmaTech Co., Ltd., China , Li, Ge Wu Xi PharmaTech Co., Ltd., China , Ando, Ryoichi Mitsubishi Pharma Corporation, Japan

From page :

455

To page :

458

Abstract :

We report herein an optimized practical synthesis of three novel 7-substituted eudistomin analogs(1-3). The total syntheses of these complex tetracyclic molecules were completed in 22 steps from the requisite7-substituted indoles.

Keywords :

Eudistomin analogs , total Synthesis , Pictet , Spengler cyclization , diasteroselectivity , demethylation

Journal title :

letters in organic chemistry

Journal title :

letters in organic chemistry

Record number :

2718025

Link To Document :

https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2718025