Title of article :
Methyl 2-Methoxycarbonyl-3-Phenylpropionate Derivatives: A New Type of Angiotensin Converting Enzyme Inhibitors
Author/Authors :
Cai, Xiao-Hua Guizhou University for Nationalites - College of Chemistry and environmental Science, China , Cai, Xiao-Hua HuaiHua Medical College - Department of pharmaceuticals, China , Xie, Bing Guizhou University for Nationalites - College of Chemistry and environmental Science, China , Guo, Hui Guizhou University for Nationalites - College of Chemistry and environmental Science, China
Abstract :
Methyl 2-methoxycarbonyl-3-phenylpropionate derivatives were prepared, and their inhibitory activities for angiotensin converting enzyme (ACE) were evaluated. The inhibitiory activity of methyl 3-{4-[2-[N-(4-methylbenzylphenyl)methyl,N-methylamino]ethoxy]phenyl} -2-methoxycarbonylpropionate (5b, IC50= 0.0039 ìM) and methyl 3-{4-[2-[N-bis(4-methoxy phenyl)methyl,N-methylamino]ethoxy]phenyl}-2-methoxycarbonyl propionate (5d, IC50 = 0.0027(mu)M) was higher than that of control drug captopril (IC50 =0.0075(mu)M)
Keywords :
Hypertension , 2 , methoxycarbonyl , 3 , phenyl propionate derivative , ACE inhibitor
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
