Title of article :
Recent Advances in the Field of Peptide Nucleic Acids
Author/Authors :
Howarth, Nicola M. Heriot-Watt University - School of Engineering Physical Sciences - Department of Chemistry, UK
Abstract :
Since their development, peptide nucleic acids (PNAs) have attracted much attention as potential pharmacological regulators of gene expression. Currently, applications of PNAs are restricted through deficiencies in target specificity, aqueous solubility and cellular uptake. This highlight reviews syntheses and hybridisation properties of recent PNA analogues designed to address these limitations.
Keywords :
Peptide nucleic acids , PNA analogues , backbone modifications , side chain modifications , nucleobasemodifications , hybridisation properties
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
