Author/Authors :
Wang, Feng Zhejiang University - College of Pharmaceutical Sciences - Department of Traditional Chinese Medicine and Natural Drug Research,, China , Jiang, Xiangrui Zhejiang University - College of Pharmaceutical Sciences - Department of Traditional Chinese Medicine and Natural Drug Research, China , Hu, Lihong Zhejiang University - College of Pharmaceutical Sciences - Department of Traditional Chinese Medicine and Natural Drug Research, China , Dong, Shengyi Zhejiang University - College of Pharmaceutical Sciences - Department of Traditional Chinese Medicine and Natural Drug Research, China , Wu, Xiumei Zhejiang Hisun Naturelite Pharmaceutical R D Co., Ltd., China , Bai, Hua Zhejiang Hisun Naturelite Pharmaceutical R D Co., Ltd., China , Zhang, Yongmin Zhejiang University - ZJU-ENS Joint Laboratory of Medicinal Chemistry, .China , Stöckigt, Joachim Johannes-Gutenberg Universität Mainz - Institut für Pharmazie - Lehrstuhl für Pharmazeutische Biologie, Germany , Stöckigt, Joachim Zhejiang University - College of Pharmaceutical Sciences - Department of Traditional Chinese Medicine and Natural Drug Research, China , Zhao, Yu Zhejiang University - College of Pharmaceutical Sciences - Department of Traditional Chinese Medicine and Natural Drug Research, China , Zhao, Yu Zhejiang University - ZJU-ENS Joint Laboratory of Medicinal Chemistry, China
Abstract :
A novel and convenient synthetic approach to ubiquinone-10 was reported via the SN2 -typenucleophilic displacement reaction between copper-catalyzed Grignard reagent and the secondary allylicacetate, which was suitable for the large-scale production of ubiquinone-10.
Keywords :
SN2 , type reaction , copper , catalyzed , Grignard reagent , secondary allylic acetate , regioselectivity , stereoselectivity
