Title of article
Application of Bioreduction by Microorganisms in the Enantioselective Synthesis of Alpha-Substituted-1-Phenylethanols
Author/Authors
Andrade, Leandro H. Universidade de São Paulo - Instituto de Química - Laboratório de Química Fina e Biocatálise, Brazil , Polak, Roberta Universidade de São Paulo - Instituto de Química - Laboratório de Química Fina e Biocatálise, Brazil , Porto, André L.M. Universidade de São Paulo - Instituto de Química - Laboratório de Química Fina e Biocatálise, Brazil , Schoenlein-Crusiusb, Iracema H. Seção de Micologia e Liquenologia - Instituto de Botânica, Brazil , Comasseto, João V. Universidade de São Paulo - Instituto de Química - Laboratório de Química Fina e Biocatálise, Brazil
From page
613
To page
618
Abstract
The enantioselective bioreduction of alpha-substituted-acetophenones 1,2 was carried out with cellsof fungi to give the corresponding chiral alcohols in good yield and high enantioselectivity (up to 99%). Thechiral alcohols 3 and 4 obtained by this methodology are important intermediates for the asymmetricsyntheses of chiral drugs. The enantioselectivity presented by several fungal strains was anti-Prelog.
Keywords
Bioreduction , hydrolysis , ketone , chiral alcohol , fungus.
Journal title
letters in organic chemistry
Journal title
letters in organic chemistry
Record number
2718049
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