Title of article
An Efficient Route to Thieno[2,3-d]pyrimidine Derivatives by Tandem [2,3] and [3,3] Sigmatropic Rearrangement
Author/Authors
Majumdar, Krishna C. Department of Chemistry - University of Kalyani, Kalyani 741235, W.B., India , Pal, Nilasish Department of Chemistry - University of Kalyani, Kalyani 741235, W.B., India , Chattopadhyay, Sudip K Department of Chemistry - University of Kalyani, Kalyani 741235, W.B., India
Pages
3
From page
709
To page
711
Abstract
Synthesis of biologically important thieno[2,3-d]pyrimidine derivatives 6a-f in 65-78% yields have
been reported. The conditions applied here are based on the less studied tandem rearrangement protocol. The
precursor sulfides in 73-85% were prepared from N,N-dimethyl-6-cholouracil and 1-aryloxy-4-chlorobut-2-yne
by phase transfer catalyzed reaction condition.
Keywords
thieno[2,3-d]pyrimidine , m-chloroperoxybenzoic acid , [2,3] and [3,3] sigmatropic rearrangement
Journal title
letters in organic chemistry
Serial Year
2006
Journal title
letters in organic chemistry
Record number
2718067
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