Title of article :
Facile Synthesis of C3-Symmetric Tripodal β-Hydroxy Amide Ligands and Their Ti (IV) Complex-Catalyzed Asymmetric Addition of Diethylzinc to Aldehydes
Author/Authors :
Fang, Tao Peking University - College of Chemistry and Molecular Engineering - Key Laboratory of Bioorganic Chemistry andMolecular Engineering, Beijing National Laboratory for Molecular Sciences (BNLMS), China , Xu, Jiaxi Peking University - College of Chemistry and Molecular Engineering - Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering, China , Du, Da-Ming Peking University - College of Chemistry and Molecular Engineering - Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering, China
Abstract :
Chiral C3-symmetric tripodal tris(b-hydroxy amide) ligands have been conveniently synthesized viathe reaction of 1,3,5-benzenetricarboxylic chloride and chiral amino alcohols, and the corresponding tris(amino alcohol) ligands were obtained via the borane reduction of amides. The asymmetric diethylzinc addition to various aldehydes catalyzed by these chiral ligand-Ti (IV) complexes gave modestenantioselectivities.
Keywords :
C3 , symmetry , b , hydroxy amide , amino alcohol , asymmetric synthesis , diethylzinc
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
