Title of article :
Diastereoselective Addition of Organolithium to Ferrocene-Carboxaldehyde Imines Derived from (R)- and (S)-1-Phenylethylamine: The Effect of External Additives
Author/Authors :
Zhang, Hui-Qing Beijing Institute of Technology - School of Chemical Engineering and the Environment, China , Zhang, Hui-Qing Beijing University of Chemical Technology - School of Science, China , Zhou, Zhi-Ming Beijing Institute of Technology - School of Chemical Engineering and the Environment, China , Fang, Min Beijing Institute of Technology - School of Chemical Engineering and the Environment, China
Abstract :
An efficient and flexible asymmetric synthesis of chiral ferrocenylamines 3a-c via diastereoselective addition of organolithium compounds to chiral imines is described. High diastereoselectivity(93% de) was observed with ferrocenecarboxaldehyde imine 2b in the presence of the Lewis acids BF3•OEt2.
Keywords :
Ferrocene , optically active amines , ferrocenecarboxaldehyde imine , asymmetric addition , organolithium compounds , chiral synthesis.
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
