Title of article :
A Novel Synthesis of 2-Substituted Indole Derivatives: A Palladium Catalyzed Cross-coupling Reaction of Enol Triflate Derived from N-Methyl-2-Indolone with (Alkenyl)tributylstannane and Acetylene
Author/Authors :
Wada, Akimori Kobe Pharmaceutical University, Japan , Shinmen, Masaki Kobe Pharmaceutical University, Japan , Uenishi, Jun’ ichi Kyoto Pharmaceutical University, Japan , Ito, Masayoshi Kobe Pharmaceutical University, Japan
Abstract :
A novel method for a synthesis of N-methyl 2-substituted indole was developed by a palladium catalyzed cross-coupling reaction of an enol triflate derived from the N-methyl-2-indolone with(alkenyl)tributylstannanes and acetylenes in good to excellent yields. In addition, the enol triflate derived from lactam exhibited less reactivity with respect to cross-coupling reactions as compared with those of the enol triflates of 2-coumaranone and 2-indanone.
Keywords :
Enol triflate , indolone , coupling reaction , alkenyl stannane , acetylene
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
