Title of article :
A Highly Efficient Low Temperature Modification of the Classical Ullmann Reaction
Author/Authors :
Leroux, Frédéric R. Université Louis Pasteur (ECPM) - Laboratoire de Stéréochimie, France , Simon, Roger Université de Lausanne, Switzerland , Nicod, Nathalie Université de Lausanne, Switzerland
Abstract :
The efficient synthesis of sterically demanding tetra-substituted biaryls by means of a one-pot three steplow-temperature modification of the classical Ullmann reaction is reported. The major benefit of this methodology lies in the ready synthesis of polybrominated biaryls, which can be subsequently functionalizedinto various target molecules by means of regioselective halogen/metal permutations.
Keywords :
Ullmann reaction , C , C coupling , aryllithium , copper
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
