Title of article
EVALUATION OF SAFETY OF TOBRAMYCIN AND PIPERACILLIN COMBINATION ON RABBIT KIDNEY
Author/Authors
ZAHEER, ZUJAJA King Edward Medical University - Department of Pharmacology, Pakistan , CHIRAGH, SADIA King Edward Medical University - Department of Pharmacology, Pakistan
From page
110
To page
116
Abstract
Tobramycin, an aminoglycoside, and piperacillin, an antipseudomonal penicillin, are widely used to treat Gram –ve infections. Their concurrent use is recommended because of their synergistic action and prevention of resistant strains against monotherapy. This experimental work was aimed to study the effects and interaction of these important drugs on rabbit kidney. Male rabbits were administered tobramycin, piperacillin, and tobramycin plus piperacillin for 21 days (n = 6 in each group). Blood and urine samples were collected on day 0, 11, and 21. Blood was analyzed for BUN, serum creatinine, serum potassium, and serum sodium while urine was analyzed for urine volume, creatinine, albumin and specific gravity. Renal creatinine clearance was calculated. Results showed some change in renal function with use of tobramycin but piperacillin neither changed the renal function nor did augment the toxic effect of tobramycin so it was concluded that combination of both drugs in safe
Journal title
BioMedica
Journal title
BioMedica
Record number
2718799
Link To Document