OVULATION INDUCTION USING LAPAROSCOPIC OVARIAN DRILLING IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME: PREDICTORS OF SUCCESS

Background: Anovulatory infertility is present in 75% of patients with polycystic ovarian synd-rome (PCOS), in addition to oligomenorrhoea and signs and symptoms of hyperandrogenism.Objective: This study was performed to find the role of laparoscopic ovarian drilling (LOD) in cor-recting anovulation, menstrual irregularities and failure of conception. Possible role of the factors as the predictors of success was also studied.Method: This prospective cohort study included 49 women who were diagnosed with PCOS and anovulatory infertility. These patients had already tried various ovulation induction drugs for conception, and underwent LOD between January 1, 2006 untill December 31, 2008 in the Department of Gynaecology and Obstetrics, at the Tertiary Care Hospital, Lahore. The major outcome measures spontaneous ovulation, menstrual regularity after LOD and influence of various pre-operative characteristics on pregnancy rates.Results: Among 49 patients 33 (67.3%) started to menstruate regularly and ovulated spontaneously in 59.2%, of them 23 (46.9%) conceived. Younger age (less than 25 years), duration and infertility less than 5 years and higher LH (more than 12 IU/lit) emerged as clinically significant factors to have impact on successful outcome. BMI 27 Kg / m2, cycle pattern, morphology of ovary, LH / FSH ratios did not manifest significant role.Conclusion: Women with PCOS respond favourably to LOD.