Multiple Associations of Clinicopathological Characteristics and Risk Factors of Colorectal Cancer in the Iranian Population

Background: Previous studies have demonstrated that clinicopathological features of colorectal cancer (CRC) could be diverse in different CRC patients groups. The present study aimed to analyze the association between clinicopathological characteristics and the risk factors in different CRC patients groups, which is categorized by sex, family history, age, and also primary tumor site in the Iranian CRC patients. Method: In this cross-sectional study, we included 304 patients with CRC. The data of clinicopathological features were collected from documented pathology reports. Subsequently, we carried out multiple analyses to discover the association among these elements. Results: Our analysis demonstrated that there was a significant difference between men and women regarding the mean age at diagnosis, tumor locations, mean size of tumors, positive family history, smoking status, and physical activity (P <0.05). Out of all the patients, 22.4% had a positive family history of cancer. The patients with a positive family history just have lower mean age, body mass index (BMI), and higher physical activity compared with patients without family history of cancer (P <0.001). 31.9% of the patients were in the age group of below 55 and 68.1% were in the age group of 55. The majority of our patients in <55 age group were male, in which the subjects had higher physical activity and lower BMI, compared with patients in ≥55 group (P<0.05). Based on our analysis, there was no significant difference between pathological features such as tumor grade, stage, size, and the risk factors including BMI and physical activity in different tumor locations (P >0.05). Conclusion: Gaining information about the association between clinicopathological characteristics and the risk factors in CRC could provide a better understanding of disease pathogenesis and consequently, improve the management of diseases.