BIOCHEMICAL CHANGES IN GOLD KUSHTA INDUCED NEPHROTOXICITY IN RATS

Background and Objectives: This experimental study was designed to evaluate nephrotoxicity of indigenous gold preparations (Kushtas) in Wistar rats. There were biochemical changes observed in the rodents resulting from renal damage, after the administration of indigenous gold preparations. Methodology: The study was conducted in a total of 28 healthy Wistar rats, each weighing 200 – 250 grams. The rats were randomly divided into 4 groups each containing 7 rats. Group I was taken as control, Group II was given single dose (0.15 mg) of gold kushta, Group III received double dose (0.3 mg) kushta, and Group IV double dose kushta (0.3 mg) along with BSA (Bovine Serum Albumin) 75 mg. Biochemical parameters included spot urinary proteins and serum creatinine. Results: The changes were observed in all the above groups except group G I which served as control. More severe changes were seen in high dose groups and the group given BSA injection alongwith kushta (Group III, IV). Conclusions: This experiment proves that the herbomineral preparations (kushta) of gold which are nephrotoxic in rats may have similar toxic effects in human beings.