SERUM IMMUNOGLOBULINS an‎d CRP LEVELS IN AUTISTIC CHILDREN

Background and Objectives: The objective of this study was to determine and compare the serum CRP and immunoglobulin levels in autistic children and healthy controls. It was an observational cross sectional study design. Two groups were designed in the study, one for controls and other for patients. Control group include the normal, healthy individuals with no infection, inflammation or immune abnormality. Patient group include the autistic children who fulfil the DSM IV criteria. Methodology: Immunoglobulins (IgG, IgM, IgA) and CRP levels were measured in serum of autistic patients and controls. CRP levels were measured by semi quantitative agglutination method while immunoglobulin levels were measured by immunoturbidity technique. All collected information was entered in to SPSS version 20.0 and analysed through its statistical package. Results: In this study statistically significant elevated serum CRP levels and decreased serum IgG levels were observed in autistic patients as compared to control. Conclusion: The results of this study showed that there are abnormalities in the immune system of autistic patients.