EFFECT OF CINNAMON BARK OIL ON CADMIUM INDUCED TESTICULAR TOXICITY IN MALE ALBINO RATS

Background and Objectives: The present experimental study was designed to investigate the toxic changes in the testes of cadmium treated rats and evaluate the protection provided by cinnamon bark oil. Methods: Thirty male albino rats were randomly divided into three groups A, B and C. Group A served as control and received 1ml/100gm/day of distilled water and 0.5ml/100gm/day of olive oil for 14 days by oral gavage. Group B received 1.5mg/100gm/day of CdCl2 dissolved in distilled water and 0.5ml/ 100gm/day of olive oil for 14 days. Group C received CdCl2, 1.5mg/100gm/day in distilled water and 100mg/kg/day of cinnamon bark oil CBO in 0.5ml/100gm of olive oil for 14 days by oral gavage. Animals were sacrificed on day 15 and testes were removed. Results: Examination of gross parameters between the control and experimental groups did not show any difference which was statistically significant. Histological sections, stained with H E were examined under light microscope. The administration of cadmium caused a significant decrease in germinal epithelium thickness and Johnson’s score. However, significant improvements were observed in these parameters after the concurrent administration of CdCl2 with CBO. Conclusion: The results of this study revealed that CBO has protective effect against the toxic effects in rat testes induced by cadmium.