Author/Authors :
Bolandi, Somayeh Department of Obstetrics and Gynecology - School of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Nakhaee, Maryam Department of Obstetrics and Gynecology - School of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Shirinzadeh, Laya Department of Obstetrics and Gynecology - School of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Jafarian, Amir Hossein Department of Pathology - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Davachi, Behrooz Department of Radiology - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Zavari, Tahereh Department of Obstetrics and Gynecology - School of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Shirzadeh, Fatemeh Department of Obstetrics and Gynecology - School of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Yousefi, Zohreh Department of Obstetrics and Gynecology - School of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran
Abstract :
Background: The aim of this study was to estimate the overall survival (OS) and
relapse free survival (RFS) of the non-epithelial ovarian tumors (NEOTs) of ovarian
germ cell tumors (OGCT) and ovarian sex cord tumors (OSCT) in Iranian women;
we also evaluated the relative prognostic factors.
Method: In this retrospective study, we screened the documents of all the women
diagnosed with OGCTs and OSCTs from 2012 to 2019. We further assessed the OS,
RFS, and different prognostic factors.
Results: A statistically significant association existed between RFS and stage of
the disease at diagnosis in OSCTs group by univariate analysis and multivariate
analysis (HR: 0.25 (95% CI (0.08-0.78), P=0.01) and multivariate analysis (HR:
0.27 (95% CI (0.08-0.97), P=0.04), respectively. The kaplan-meier analysis and the
Log Rrank (Mantel-Cox) showed a statistically significant relationship between the
stage at diagnosis and RFS in OGCT group (P=0.042). RFS was 96% for OGCT
patients, and 92.7% for OSCT patients. During the follow-up, only one patient passed
away in the dysgerminoma group; the OS rate was 98% for OGCT patients, and
100% for OSCT patients.
Conclusion: The OS and RFS obtained in this study confirmed that the ovarian
germ cell and sex cord malignancies were among the highly treatable solid tumors.
Stage can be proposed as the main prognostic factor; also, larger series of studies are
needed for detecting the prognostic significance of serum markers.
Keywords :
Survival , Ovarian cancer , Germ cell ovarian tumor , Sex cord ovarian tumor
