Author/Authors :
Motie, Mohammad Reza Surgical Oncology Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Taghizadeh, Ali Surgical Oncology Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Pourali, Leila Department of Obstetrics and Gynecology - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran) , Oshibnetaj, Mohammad Surgical Oncology Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Hasanzadeh, Elahe Metabolic Syndrome Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Jarahi, Lida Department of Community Medicine - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Moein Darbari, Somaye Department of Obstetrics and Gynecology - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Mahdizadeh, Shadi Cancer Research Center - Mashhad University of Medical Sciences, Mashhad, Iran
Abstract :
Background: Breast cancer is the most frequent malignancy and the leading cause
of cancer-related death among women all around the world. In Iran, the mean age of
the patients is approximately 10 years younger than that in other countries. We
conducted the present study to assess the risk factors of breast cancer among Iranian
women in Mashhad.
Method: This case-control study was carried out between February 2016 and
January 2018 on 460 women (230 cases and 230 controls) in the academic hospitals
of Mashhad. The data from our cases and controls were collected and analyzed using
SPSS version 18.0 software (SPSS Inc., Chicago, IL, USA). We employed logistic
regression models and frequency tables to estimate odds ratio (OR) and to examine
the predictive effect of each factor on breast cancer risk. P < 0.05 was considered to
be significant.
Results: According to multivariate analysis, there was significant associations
between breast cancer risk and body mass index (BMI) (Odds ratio (OR), 1.1; 95%
Confidence interval (CI), 1.0-1.2), age at menarche (OR, 0.56; 95% CI, 0.47-0.68),
menopausal age (OR, 1.1; 95% CI, 1.0-1.1), family history of non-breast malignancies
(OR, 7.9; 95% CI, 2.2-21.1), and oral contraception pills (OR, 3.1; 95% CI, 8.34-
1.16).
Conclusion: This study revealed that age at menarche, family history of non-
breast cancer malignancies, BMI, menopausal age, and oral contraception pills were
significantly associated with breast cancer.
