Title of article :
Use of off-label compounded oral sildenafil in the management of persistent pulmonary hypertension of the newborn: A case report
Author/Authors :
Daniyan ، Olapeju Department of Paediatrics - Teaching Hospital - Alex Ekwueme Federal University , Ezeanosike ، Obumneme Department of Paediatrics - Teaching Hospital - Alex Ekwueme Federal University , Obu ، Dorathy Department of Paediatrics - Teaching Hospital - Alex Ekwueme Federal University , Ujunwa ، Fortune Department of Paediatrics - Teaching Hospital - Alex Ekwueme Federal University
Abstract :
We report a case of a newborn with persistent pulmonary hypertension (PPHN) due to meconium aspiration syndrome with associated lung collapse. Echocardiogram revealed features of persistent pulmonary hypertension. He was treated with compounded oral sildenafil. Oral sildenafil has proven to be effective and safe in the management of PPHN in neonates with persistent pulmonary hypertension. Therefore, in situations where inhaled nitric oxide is not available it may be used as an alternative therapy in PPHN. Further randomized controlled studies are needed to determine its efficacy and pharmacokinetics.
Keywords :
Newborn , Persistent Pulmonary Hypertension , Sildenafil
Journal title :
Journal of Cardiovascular and Thoracic Research (JCVTR)
Journal title :
Journal of Cardiovascular and Thoracic Research (JCVTR)