Author/Authors :
Masoumi, Elham Department of Immunology - Faculty of Medicine - Ilam University of Medical Sciences, Ilam, Iran - Research Committee - School of Medicine - Ilam University of Medical Sciences, Ilam, Iran , Mirzaei, Asad Parasitology department - paramedical school - Ilam University of Medical Science, Ilam, Iran - Zoonotic Diseases Research Center - Ilam University of Medical Sciences, Ilam, Iran , Ghaffari-Nazari, Haniyeh Immunogenetic and Tissue Culture Department - Immunology Research Center - Bu-Ali Research Institute - Mashhad University of Medical Sciences, Mashhad, Iran , Tahaghoghi-Hajghorbani, Sahar Research Committee - School of Medicine - Mazandaran University of Medical Sciences, Sari, Iran - Department of Immunology - School of Medicine - Mazandaran University of Medical Science, Sari, Iran , Jalali, Amir Department of Immunology - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Tavakkol-Afshari, Jalil Immunogenetic and Tissue Culture Department - Immunology Research Center - Bu-Ali Research Institute - Mashhad University of Medical Sciences, Mashhad, Iran
Abstract :
Background: The precise responsible mechanism of pre-eclampsia remains controversial however, recent data suggest a main role of the abnormal activation of the adaptive immune system and Apoptosis. In this study, we
have measured serum levels of Fas/Fasl as two important members of extrinsic apoptotic pathway in patient
with pre-eclampsia.
Methods: 207 participants including 99 pre-eclampsia patients and 108 age and sex-matched normal pregnant
women were involved in the case-control study. Plasma sample from each participant was collected and stored
at –20 ̊C until batch processing.
Serum levels of Fas and Fas ligand were measured by ELISA for each participant including 99 pre-eclampsia
patients and 108 normal pregnant women. Following a test of statistical normality, nonparametric data were
analyzed by Mann-Whitney.
Results: sFas levels in case group was significantly higher than controls; 584 (397-892) pg/ml in cases opposed
to 341 (213-602) pg/ml in controls (p value< 0.01). sFasL in pre-eclampsia women was a little lower than
controls; 255 (173-318) pg/ml and in case group compared to 265.5 (184-381.5) pg/ml in controls.
Conclusions: We have found the increased levels of sFas in patients with pre-eclampsia in compare with the healthy pregnant women. It seems that abnormality in sFAS is related with pre-eclampsia.
Keywords :
Pre-eclampsia , Pregnancy , sFAS , sFASL , Apoptosis
