Author/Authors :
Davoodi, Akram Student Research Committee - School of Medicine - Kermanshah University of Medical Sciences, Kermanshah, Iran , Lotfi, Ramin Lung Diseases and Allergy Research Center - Research Institute for Health Development - Kurdistan University of Medical Sciences, Sanandaj, Iran , Mortazavi, Hamidreza Department of Pediatrics - School of Medicine - Kermanshah University of Medical Sciences, Kermanshah, Iran , Gorgin Karaji, Ali Department of Immunology - School of Medicine - Kermanshah University of Medical Sciences, Kermanshah, Iran , Rezaiemanesh, Alireza Department of Immunology - School of Medicine - Kermanshah University of Medical Sciences, Kermanshah, Iran , Salari, Farhad Department of Immunology - School of Medicine - Kermanshah University of Medical Sciences, Kermanshah, Iran
Abstract :
Background: Retinoic acid (RA) plays a key role in naïve T cell differentiation into FOXP3+ Treg cell in the
respiratory airways. The present study aims to investigate RA and Treg-related cytokine serum levels, salivary
IgA levels, FOXP3 and IL-4 gene expression, and the relationships between RA serum levels and Treg-related
cytokines in allergic rhinitis (AR) patients and healthy controls.
Methods: Salivary IgA and serum IgE, RA, IL-10, and TGF-β concentrations were measured by ELISA in 37
AR patients and 30 age- and sex-matched healthy controls.
Results: IL-10 and TGF-β concentrations were significantly less in AR patients than in healthy controls (p<
0.01 and P< 0.0001, respectively). Salivary IgA was significantly greater in patients than in controls (p< 0.05).
RA was not significantly different between patients and controls (p> 0.05); however, a significant positive
correlation was found between serum RA and both IL-10 and TGF-β in AR patients.
Conclusions: Our data suggest that RA may influence AR risk via affecting the TGF-β and IL-10 production.
Keywords :
Allergic Rhinitis , Interleukin-10 , Obesity , Retinoic Acid , Transforming Growth Factor-β
