Author/Authors :
Roshani, Fatemeh Department of Genetics - Nourdanesh Institute of higher Education - Myme, Esfahan, Iran , Delavar Kasmaee, Hossien medical university of Shahid Beheshti, Tehran , Falahati, Kowsar Medical Genetic Department - National Institute of Genetics Engineering and Biothechnology, Tehran, Iran , Arabzade, Ghazaleh Department of Genetics - Nourdanesh Institute of higher Education - Myme, Esfahan, Iran , Sohan Forooshan Moghadam, Atefeh Department of Genetics - Nourdanesh Institute of higher Education - Myme, Esfahan, Iran , Sanati, Mohammad Hossein Medical Genetic Department - National Institute of Genetics Engineering and Biothechnology, Tehran, Iran
Abstract :
Background: Etiology of multiple sclerosis is non-clarified. It seems that environmental factors impact
epigenetic in this disease. Micro-RNAs (MIR) as epigenetic factors are one of the most important factors in
non-genetically neurodegenerative diseases. It has been found MIR-144 plays a main role in the regulation
of many processes in the central nervous system. Here, we aimed to investigation of MIR-144 expression
alteration in Multiple sclerosis (MS) patients.
Methods: In this study 32 healthy and 32 MS patient's blood sample were analyzed by quantitative
Real-Time PCR method and obtained data analyzed by REST 2009 software.
Results: Analysis of Real-Time PCR data revealed that miR-144 Increase significantly in MS patients
compared to healthy controls.
Conclusions: The increase of MIR-144 expression in MS patients is obvious. MIR-144 can be used
as a biomarker of MS and help to early diagnosis and treatment of this disease.
