Author/Authors :
mohamed, mohamed a. al‑azhar university - faculty of dentistry - department of oral pathology, Cairo, Egypt , kamal, kamal a. al‑azhar university - faculty of dentistry - department of oral pathology, Cairo, Egypt , nasr, galal a. al‑azhar university - faculty of dentistry - department of oral biology, Cairo, Egypt , alqarni, ali a. taif university - faculty of dentistry - department of oral medicine, Taif, Saudi Arabia
Abstract :
Aim To study the evaluation of the expression of Bcl‑2 and Bax markers in polymorphous low‑grade adenocarcinoma (PLGA) and epithelial–myoepithelial carcinoma. Materials and Methods Hematoxylin and eosin and streptavidin–biotin immunoperoxidase staining techniques was used to detect the expression of Bcl‑2 and Bax protein in five cases of PLGA and five cases of epithelial–myoepithelial carcinoma. Evaluation of immunostaining was done by image analysis computer system. Results Showed that there was a statistically significant difference (P 0.001) in means of Bcl‑2 and Bax expression between PLGA and epithelial–myoepithelial carcinoma. Conclusion The expression of Bcl‑2 and Bax could be used as an effective biomarker to predict aggressive biologic behavior of PLGA and epithelial–myoepithelial carcinoma.
Keywords :
Bax , Bcl‑2 , epithelia–myoepithelial carcinoma , polymorphous low‑grade adenocarcinoma , salivary gland
