Hypomelanosis of Ito Associated with Neuroblastoma

Hypomelanosis of Ito (HI) is a rare neurocutaneous disorder described for the first time in 1952 as incontinentia pigmenti achromians. The consistent feature of the disease is a characteristiccutaneous hypopigmentation areas following the lines of Blaschko, often associated with ocular, musculoskeletal and neurological abnormal ities(1). In this paper we describe a 1.5 year old child with HI and rapidly progressing neuroblastoma. To our knowledge, associated neuroblastoma wasreported only once in the literature by Oguma et aI., 1996 (2).