Basic concepts of medical genetics,pathogenetics,part 5

Accurate post-translation structural configuration of newlysynthesized polypeptide chains is a fundamental conformational modification for most proteins to become functionally active biomolecules. The maturation from primary to quaternary protein structure involves many changes, e.g. folding and maintenance of steric and spatial relationships between the different domains of the protein. Conformational defects in proteins that might happen during these modifications can lead to formation of misfolded and/or aggregated non-functional molecules.