Lack of association between TRAF1/C5 rs10818488 polymorphism and rheumatoid arthritis in Iranian population

Rheumatoid arthritis (RA) is a multifactorial disorder related to the inflammatory response system with debilitating and painful conditions. Both genetic and environmental factors,with unknown etiology,play important roles in this disease pathogenesis. Recently,TRAF1/C5 (Tumor Necrosis Factor Receptor-Associated Factor 1/. Complement Component 5) polymorphism associated with increased risk for RA has been studied in different populations worldwide,and inconsistent results have been obtained. rs10818488 allele is located on TRAF1/C5 intergenic region,and has been predicted to be functional. A total of 100 sex- and age-matched people including RA patients (n= 50) and healthy individuals (n= 50) from Iran have been entered in this study and genotyped for rs10818488 (A/G) polymorphism,using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). In our study,rs10818488 allele was not associated with risk for RA in Iranian population (p . 0.05,OR = 1.27,95% CI = 0.72-2.23). Results revealed that this allele might be population-specific and not to be associated with their corresponding gene pool. However,further analyses are required to clarify other RA-associated markers in our community. © 2012.