The role of microRNAs on angiogenesis and vascular pressure in preeclampsia: The evidence from systematic review

Background: In pre-clinical stage of preeclampsia,placental angiogenesis is impaired leading to hypoxic placenta and dysregulation of pro- and anti-angiogenetic factors. As a consequence,these cause elevated systemic vascular resistance,vasoconstriction and hypertension in clinical stage of preeclampsia. Dysregulation of microRNAs (miRNAs) has been observed among preeclampsia patients and they are involved in several aspects of preeclampsia pathogenesis. Aims: To evaluate the roles of miRNAs in angiogenesis and vascular pressure in preeclampsia. Material and methods: Articles from MEDLINE database (between 2007 and February 2015) were searched by using the combination of Medical Subject Headings (MeSH terms) preeclampsia