ACE DD genotype associated with the female Chronic Kidney Disease patients of Tamilnadu population

Background: The Renin-Angiotensin System (RAS) is an important regulator for blood pressure and kidney disease. The level of vaso active peptide Angiotensin-II is mainly determined by the RAS enzyme angiotensin converting enzyme-1 (ACE-1). Aim: To investigate the association of ACE I/D polymorphism and Chronic Kidney Disease (CKD) in south India. Methods: In the present study,we have collected CKD patients (. n=. 147) and control subjects (. n=. 211) from Tamilnadu. Genotyping was carried out by polymerase chain reaction (PCR) on the basis of allele specific primers. Results: The DD genotype is associated with the female population (OR-CI. =. 2.40 (1.05-5.51),p=. 0.04) as compared to the male population (OR-CI. =. 0.75 (0.37-1.51),p=. 0.42). Further,we found the over representation of I - allele (homozygous II and heterozygous ID) in unaffected males [OR (CI) - 0.58 (0.32-1.04),p=. 0.07] which suggests its protective role in male population. Conclusion: The DD genotype of ACE is associated with CKD in south India. © 2014 .