Author/Authors :
Habibi, F Nuclear Engineering Department - Shiraz University, Shiraz, Iran , Faghihi, R Nuclear Engineering Department - Shiraz University, Shiraz, Iran , Zolghadri, S Radiation Application Research School - Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran , Yousefnia, H Radiation Application Research School - Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran , Sina, S Radiation Research Center - Shiraz University, Shiraz, Iran , Mohammadpour-Ghazi, F Radiation Application Research School - Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
Abstract :
Background: In recent years, Gallium-68 citrate has become known as an alternative radioisotope in nuclear medicine. As for its influences, 68Ga-based tracers have already
been proposed as agents for positron emission tomography. In this research, the
values of human absorbed dose for 68Ga-citrate and 67Ga-citrate were estimated using
the medical internal radiation dose method based on biodistribution data in rats.
Materials and Methods: 68Ga/67Ga-citrate was prepared from eluted 68Ga/67Ga-Cl3 and
sodium citrate under multiple reaction forms. The biodistribution of 68Ga/67Ga–
citrate radiolabeled compounds was investigated by dissection of five male rats at
specific times after injection. The organs of the rats were removed and counted.
Percentage of injected dose per gram was determined for each rat organ and the
human absorbed dose was extrapolated using the rats’ data. Results: The results of
estimating the human absorbed dose illustrate that 68Ga-citrate caused a much lower
human absorbed dose compared with 67Ga-citrate. Conclusion: According to the
results, it may be concluded that 68Ga-citrate, despite the better quality of PET
imaging, is much safer in terms of absorption dose compared with 67Ga-citrate, and from this point of view, it is a more appropriate agent for imaging applications.
Keywords :
Internal radiation dose , MIRD , 68Ga-citrate , 67Ga-citrate
