A Systematic Review and Data Analysis on the Epidemiology of Tuberculosis and Diabetes Mellitus

Objectives: This study aims to analyze epidemiological data that diabetes leads to increased susceptibility to initial tuberculosis infection or if diabetes leads to increased progression from latent tuberculosis to active tuberculosis. Methods: A simplified MEDLINE search method has been used in this study. The PubMed’s Clinical Queries, which have "research methodology filters" to study the patterns, causes, and clinical effects of health and the disease conditions in defined populations, were explored and extracted. Results: Using the keyword-based queries in PubMed/ Medline and Embase, 38 relevant published studies were collected from 1970 to 2020. Published studies from the literature search were combined with the observational studies of summary statistics which can further be used for clinical trials. Conclusion: The high prevalence of diabetes is a factor that increases the incidence of tuberculosis and is considered in the fight against tuberculosis worldwide. There have been many significant recent advances in knowledge regarding diabetes-associated tuberculosis's epidemiology, management, and control. J Microbiol Infect Dis 2021; 11(4):191-200.