Author/Authors :
Kamyab Hesari, Kambiz Dermatopathology Department - Razi Hospital - Tehran University of Medical Sciences, Tehran, Iran , Ghanadan, Alireza Dermatopathology Department - Razi Hospital - Tehran University of Medical Sciences, Tehran, Iran , Azhari, Vahidehsadat Dermatopathology Department - Razi Hospital - Tehran University of Medical Sciences, Tehran, Iran , Taraz Jamshidi, Shirin Pathology Department - Imam Reza Hospital - Mashhad University of Medical Sciences, Mashhad, Iran , Amiri, Reza Dermatopathology Department - Razi Hospital - Tehran University of Medical Sciences, Tehran, Iran , Mahmoudi, Hamidreza Autoimmune Bullous Diseases Research Center - Tehran University of Medical Sciences, Tehran, Iran , Salehi Farid, Ali Autoimmune Bullous Diseases Research Center - Tehran University of Medical Sciences, Tehran, Iran , Nili, Ali Autoimmune Bullous Diseases Research Center - Tehran University of Medical Sciences, Tehran, Iran , Borzouei, Anahita Dermatopathology Department - Razi Hospital - Tehran University of Medical Sciences, Tehran, Iran , Daneshpazhooh, Maryam Autoimmune Bullous Diseases Research Center - Tehran University of Medical Sciences, Tehran, Iran
Abstract :
Background: Lichen planopilaris (LPP) is the most common form of immune-mediated scarring alopecia. We evaluated the histopathologic features of LPP in vertical sections of scalp
biopsies and compared findings between the scarring and nonscarring
phases of the disease.
Methods: From June 2019 to June 2020, vertically sectioned
scalp biopsies of 70 new cases of LPP were examined (H&E)
according to North American Hair Research Society criteria.
Furthermore, patients were divided into two groups based on
either the presence or the absence of vertical fibrous bands, and
other histopathological features were compared between these
two groups.
Results: Characteristic findings of LPP were perifollicular
lymphocytic infiltration (97.1%), follicular interface degeneration
(60%), and perifollicular plasmacytic infiltration (21.4%). Vacuolar
degeneration in the dermo-epidermal junction (38.6%), perifollicular
lamellar fibroplasia (67.1%), loss of sebaceous glands (87.1%),
perifollicular cleft formation (28.6%), and vertical fibrous tracts
(65.7%) were also found. Furthermore, we found a significant
correlation between the presence of fibrous tracts with both loss
of sebaceous glands (P = 0.005) and the presence of lamellar
fibroplasia (P = 0.015).
Conclusion: The most common findings in the histopathological
examination of LPP slides are perifollicular lymphocytic infiltration
and loss of the sebaceous glands. Furthermore, sebaceous gland loss and perifollicular lamellar fibroplasia correlate with the scarring phase of LPP.
