Author/Authors :
Momenzadeh, Akram Cutaneous Leishmaniasis Research Center - Mashhad University of Medical Sciences, Mashhad, Iran - Department of Biochemistry - Faculty of Science - Payame Noor University, Mashhad, Iran , Khajavi, Mahboubeh Cutaneous Leishmaniasis Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Kazemi, Mohammad Reza Student Research Committee - Mashhad University of Medical Sciences, Mashhad, Iran , Teimoorian, Mehrdad Cutaneous Leishmaniasis Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Livani, Fatemeh Department of Dermatology - Golestan University of Medical Sciences, Gorgan, Iran , Saleh Moghadam, Masoud Department of Biochemistry - Faculty of Science - Payame Noor University (Pnu), Mashhad, Iran , Layegh, Pouran Cutaneous Leishmaniasis Research Center - Mashhad University of Medical Sciences, Mashhad, Iran
Abstract :
Background: Pemphigus vulgaris (PV) is an autoimmune disease with worldwide distribution. Human leukocyte antigen G (HLA-G) is postulated to be associated with this inflammatory
and autoimmune condition. However, its role has not been well
established in the literature. The study aimed to evaluate the
plasma level of HLA-G in PV patients and assess its correlation
with disease severity and compare it with normal subjects.
Methods: Thirty PV patients were enrolled in this cross-sectional
study. A blood sample was taken from each participant; samples
were analyzed for the soluble HLA-G (sHLA-G) plasma level
by applying an ELISA kit (sHLA-G ELISA kit; Exbio, Czech
Republic). Patients’ clinical and demographic data were recorded
and analyzed.
Results: Higher levels of sHLA-G were seen in PV patients
compared to the control group (P < 0.05). There was a negative
linear relationship between plasma HLA-G level and PV based
on all ABSIS indices except for oral involvement (-1 < R < 0);
however, these correlations were not statistically significant
(P 0.05).
Conclusion: Our data showed higher plasma sHLA-G levels in PV patients, which did not correlate with disease severity.
