Title of article :
Green and Efficient Synthesis of Baclofen
Author/Authors :
Fernandes ، Pearl Rhea Department of Food Nutrition and Dietetics - Milagres College , Madnala ، Ashwini SIES College of Arts, Science and Commerce Sion , Donde ، Nisha Karmaveer Bhaurao Patil College , Pawar ، Amit Karmaveer Bhaurao Patil College , Sonawale ، Maryappa Veer wajekar ASC College Phunde
Abstract :
Baclofen is a Gamma Amino Butyric acid (GABA) agonist to relax skeletal muscles. It is especially effective in treating muscular spasticity. In this research, we now describe the synthesis of Baclofen using a new approach which begins with 4- chlorobenzaldehyde. We have carried all reactions by the green method. It gives the better yield. The identity of this product was confirmed by spectral analysis and compared with the standard Baclofen. New and eco-friendly approach was developed for the synthesis
Keywords :
GABA agonist , 4 , Chlorobenzaldehyde , Cyanohydrin , Oxidizingagent , Pyridinium , Wittig type reaction , Hydrolysis , Reduction
Journal title :
Advanced Journal of Chemistry, Section B: Natural Products and Medical Chemistry
Journal title :
Advanced Journal of Chemistry, Section B: Natural Products and Medical Chemistry
