Design, Effectiveness, Limitations and Future Perspectives of CAR-T Cells: A Review Article

Context: Targeted anti-cancer approaches bring about individual therapies to combat the complexity of most malignancies and enhance their chances of success. Currently, immunotherapy, which exploits the patient s immune system to fight the disease, has made a significant progress in the success rate of cancer treatment. T lymphocytes are one of the most powerful arms of the immune system against cancer cells; however, many tumor cells can escape by hiding their peptide antigens. Evidence Acquisition: CAR-T cells can detect tumor cells HLA without any restrictions. Promising outcomes from CAR-T cell clinical trials have increased hope among cancer patients, making CAR-T cell a prospective treatment for most cancers. However, its unique toxicities and the possibility of recurrence have raised concerns among scientists. Results: Therefore, in this review, in addition to the design of CAR-T cells, we intend to discuss the process of CAR-T cell therapy in the treatment of malignancies and explore its disadvantages, advantages, and prospects. Conclusion: Despite extensive studies, it is not yet possible to confirm the role of CAR-T cells, but based on the experience of applying CAR-T cells, a definite treatment is feasible through immunotherapy and strengthening the immune system.