Author/Authors :
Vieira da Costa Almeida, Marcelo Department of Oral Medicine - Real Hospital Português de Beneficência em Pernambuco ,Paissandu, Recife - PE, Brazil , C. Moura, Antonio Department of Oral Medicine - Real Hospital Português de Beneficência em Pernambuco ,Paissandu, Recife - PE, Brazil , Santos, Lúcia Department of Oral Medicine - Real Hospital Português de Beneficência em Pernambuco ,Paissandu, Recife - PE, Brazil , Gominho, Luciana Department of Restorative Dentistry - Universidade Federal da Paraíba – UFPB, s/n, Cidade Universitária - João Pessoa, PB, Brazil , Dias Nascimento Távora Cavalcanti, Ully Department of Oral Medicine - Real Hospital Português de Beneficência em Pernambuco ,Paissandu, Recife - PE, Brazil , Romeiro, Kaline Department of Oral Medicine - Real Hospital Português de Beneficência em Pernambuco ,Paissandu, Recife - PE, Brazil
Abstract :
Introduction: Medication-related osteonecrosis of the jaw (MRONJ) corresponds to an adverse effect
of the use of drugs such as bisphosphonates and denosumab. This condition is often associated with
pain, infection, purulent secretion, paraesthesia, tooth mobility and halitosis, decreasing the patient’s
quality of life. The management of MRONJ tends to be conservative, through the guidance of oral
hygiene, antibiotic therapy and mouthwashes. However, the use of antimicrobial photodynamic
therapy (aPDT) has shown promise in the treatment of these injuries. The purpose of this article is to
report a case of MRONJ treatment associated with aPDT.
Case Report: A 75-year-old patient, with a history of breast cancer and use of intravenous Zoledronic
Acid, presented with bilateral MRONJ lesions in tuberosity on the right and left sides. Treatment was
conservatively instituted with the use of aPDT as an adjuvant. After 12 aPDT sessions, complete
regression of the lesion was observed. However, after two weeks, the presence of a new lesion was
noted, this time in the anterior region of the maxilla. The same protocol previously established was
followed and after two aPDT sessions, the patient returned with complete lesion regression.
Conclusion: The use of aPDT may represent an important adjuvant within a set of clinical protocols
in the treatment of MRONJ.
Keywords :
Low-level laser therapy , MRONJ , Photodynamic therapy , Photobiomodulation , Bisphosphonates
