Title of article :
Epidemiological, clinical and morphological aspects of kidney damage in COVID-19
Author/Authors :
Daminov, Batir Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan , Abdullaev, Sherzod Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan , Sharapov, Olimkhon Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan , Igamberdieva, Ranokhon Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan
Abstract :
The mini-review presents modern data on the epidemiology, clinical and morphological
aspects of kidney damage in COVID-19. Potential mechanisms of kidney involvement
in the clinical picture of the disease may include cytokine damage, cross-organ damage,
and systemic effects that determine the treatment strategy. These mechanisms are closely
interrelated and are especially important for individuals undergoing extracorporeal therapy
and kidney transplants. Autopsy data provide evidence of SARS-CoV-2 virus invasion
into kidney tissue with damage to tubular epithelial cells and podocytes, and erythrocyte
aggregation in persons with severe COVID-19. By including people with chronic kidney
disease in planned COVID-19 research protocols, an evidence base for effective and safe
treatments can be generated.
Keywords :
SARS-CoV-2 , COVID-19 , Pandemic , Kidney disease , Coronavirus infection , Chronic kidney disease , Acute renal failure
Journal title :
Journal of Renal Injury Prevention
