SYNTHESIS AND CHARACTERIZAITION OF BISCYCLIC p- LACTAMS AS BLOOD CHOLESTROL INHIBITORS

This study is concerned with the synthesis and characterization of the 3-(4-chlorophenyl) bicyclic azetidin -2-one 3a. This compound 3a was prepared by reacting 3-(4-chlorophenyl) acetic acid with the appropriate Schiff s base 2a in the presence of triethylamine with phosphorusoxychloride in dry dichloromethane under nitrogen atmosphere at -10°C. The active acid chloride reacts with triethylamine to generate corresponding ketene in situ which further reacts with Schiff s base to furnish corresponding 3-(4-chloroPhenyl)bicyclic azetidin 2-ones 3a.And it was a study of the activity biological to compound 3a to inhibition of cholesterol in the blood of some laboratory animals.