Design and evaluation of sesamol loaded hyaluronic acid functionalized phospholipid nanovesicles: DPPH radical scavenging potential assay

Objective(s): The unfavorable physicochemical properties of well recognized antioxidant phytoactive sesamol limits its oral bioavailability as well as potential application as an antioxidant drug. The aim of the study is to design and evaluate sesamol encapsulated hyaluronic acid anchored phospholipid nanovesicles to enhance its antioxidant potential. Methods: Drug encapsulated hyalurosomes were prepared using thin film hydration method and evaluated for particle diameter, physical stability, drug encapsulation efficiency, sesamol release behavior in vitro and DPPH radical scavenging assay. Results: The selected method was found to be effective for fabrication of phospholipid nanovesicles with particle diameter 200 ± 10.173 nm and zeta potential -29.8 ± 4.16 mV. The drug loaded hyalurosomes revealed significantly better radical scavenging potential compared to free sesamol and unloaded hyalurosomes. Conclusions: Hyaluronic acid functionalized phospholipid nanovesicles is novel phospholipid based carrier for delivery of phytoactives. Thus formulated phospholipid based system could be acceptable system for delivery sesamol with improved antioxidant potential.